In early 2018, Wendy took a brief hiatus from The Wendy Williams Show after her Graves' disease diagnosis. Graves can have long-term effects on the body in terms of high blood pressure, enlarged thyroid, and fatigue. When Wendy returned to her show in March 2018, she seemed to be on the mend for the time being.

It's unclear if her lymphedema diagnosis was related to having Graves' disease as well. But for a couple of years, the health scares and issues kept coming at Wendy, making it difficult for her to maintain her light-hearted persona on her show. In May 2020, she took another break from her show due to her struggle with Graves, but she has continued to push on.