In his career, Rowe started 45 of 47 games and had 261 fights, three interceptions, and 1.5 sacks. In the second round (47th overall) of the 2015 NFL Draft, the Philadelphia Eagles selected Rowe. On May 6, 2015, the Philadelphia Eagles signed a four-year, $4.87 million contract with Rowe, which includes a $452.248 signing bonus.
He made his professional regular-season debut at the Philadelphia Eagles season-opening 26–24 losses at the Atlanta Falcons. On January 18, 2016, the Philadelphia Eagles hired Kansas City Chief offensive coordinator Doug Pederson as their new head coach. On December 2, 2019, the Miami Dolphins signed a three-year contract extension of $16.15 million for Rowe to stay with them throughout the 2022 NFL season.
