According to Variety, Iñaki Godoy will play the main character of the series, Monkey D. Luffy. He starred in another Netflix series called Who Killed Sara?

Mackenyu will play Roronoa Zoro; Emily Rudd will play Nami; Jacob Romero Gibson will play Usopp; and Taz Skylar will play Sanji.

In a November 2021 Instagram post, Iñaki let people know that he understands how important One Piece is to fans of the series. "I’ve been doing my research on One Piece and I know how much this means to all of you," he wrote. "I wanna let you know I will do my best and I appreciate all the kindness you’ve showed me. THANK YOU FOR THE TRUST."

Even though these are five of the main members of the Straw Hats, there are still some characters that need to be added. Every good story needs a villain, for example, and as of right now, the Netflix live-action hasn't revealed one. In the One Piece manga and anime, Imu is a main villain. Although he is secretive and not much is known about him, he runs the World Government in secret, and that organization has been the cause of a number of crimes over the years.

But there are other villains that the live-action could bring back, including rival pirates. Señor Pink of the Donquixote Pirates has the attitude to make up for the fact that he isn't the scariest guy in the series. And Gecko Moria of the Thriller Bark Pirates was the main bad guy of the Thriller Arc. But he tends to have his minions fight his battles for him, so he may not be the best pick for the new show.

According to Comic Book, the creator of the original One Piece manga series, Eiichiro Oda — who has been heavily involved in the new live-action series — has said that he really likes the choices with casting. "We decided on this cast after numerous discussions involving people around the world," Oda previously said. "It'll take a bit more time to get this show done, but we'll continue to do our best to deliver a show that we're confident will be enjoyed by everyone around the world!"