After four years and three seasons on-air, Cartoon Network revealed it wouldn't be renewing the title for a fourth season. The final episode of Clarence aired in June 2018.

"I just wanted to address some questions about Clarence. Sadly the third season will be the last; we were not renewed past Season 3," head of story and voice of Clarence Spencer Rothbell wrote on his blog in 2017.

"Of course there will always be ideas and routes I wish we could have gotten to, but this season has some really stellar episodes that expand on the universe of the show and its characters in a fun way that we haven't really done before," he continued.

Spencer did not provide a reason as to why the network did not decide to renew Clarence, though the third season featured 40 episodes and aired for more than a year. By the time the program wrapped up, Clarence had aired 130 episodes.