During an interview with Elle Magazine back in 2009, Cusack was asked to succinctly describe why he never got married in five words or less. To quote his reply,
I can do it in seven: 'Society doesn't tell me what to do.'
That response was more or less in line with what he told The Guardian back in 2000. He was 34 back then and obviously unmarried. He was asked if he had girlfriends, and he honestly replied, "Sure."
He has had a few high-profile ex-girlfriends, including Jennifer Love Hewitt and Uma Thurman.
When the publication asked him head-on if he was gay, he comfortably replied that he had never been gay. Albeit, he was adamant that Gladiator was a movie about repressed gayness. But that's getting off-topic.