Season 12 of Grey’s Anatomy showed Callie and Arizona attempting to move on with their new lives as single women. To no one’s surprise, Callie wasn’t single for very long. However, no one expected her to date Dr. Penelope “Penny” Blake (Samantha Sloyan). For those unaware, Penny was one of the infuriating doctors who failed Derek when he was fighting for his life after a truck crashed into his car. Woo, the tears I cried while watching the episode “How to Save a Life” were too much!

Penny, who had been dating Callie while being a resident at Grey Sloan, didn’t sit well with many of Callie’s friends, especially Derek’s wife, Meredith. Nonetheless, they were fine until Penny received an offer to attend a fellowship in New York. Callie again agreed to move with Penny, only this time with her and Arizona’s daughter, Sofia.

Arizona refused to allow Callie to take their daughter and sued Callie for full custody. The nasty custody battle divided the hospital and resulted in Callie losing the case. Thankfully, Arizona decided it was time for them to stop the madness and agreed to arrange a custody agreement that served them both. Callie eventually moved to New York with Penny.