For starters, most of the original voice cast reprised their roles for the reboot. Penny, Dijonay Jones (Karen Malina Jones), LaCienega Boulevardez (Alisa Reyes), Zoey Howzer (Soleil Moon Frye), Oscar Proud (Tommy Davidson), and Trudy Proud (Paula Jai Parker) all sound pretty much exactly as they did in the original series.

Jo Marie Payton, fan-favorite Suga Momma Proud's original voice actress, also returned for the reboot. Suga Momma is still in love with Papi Boulevardez (Alvaro Gutierrez, also reprising his role), keeping with the running gag of the original series. Suga Momma thinks Papi is sweet-talking her when he says things in Spanish, but he's really insulting her.

Oscar Proud is just as protective of Penny as he was in the original series (Penny is 14 again in Episodes 1-2 of the reboot, not 16 like she was in the original series finale). Basically, the dynamic between the original characters is nearly identical to The Proud Family. Trudy is still Penny's hard-working veterinarian mother who recognizes that Penny is growing up. Dijonay is still unapologetically herself, and Zoey is awkwardly geeky (and also, like, five inches taller).

LaCienega makes her first appearance in Episode 1 with a bit of a beauty problem (her face is covered in zits and facial hair). Michael (EJ Johnson) quickly spruces up LaCienega, bringing her back to her original series classic look. That's one change from the original series: while Michael was teased for being more feminine in the original series, the show never made it clear that he was gay. In the reboot, Michael is openly gay and gender-fluid.