Frank is a chef and the owner of several restaurants, including Supper, Frank Restaurant, and Lil Frankies. He opened his first restaurant, Frank, in 1988. Prisinzano opened another restaurant, Lil Frankie’s, in January 2002. In April of that year, Frank launched Supper. During the Covid-10-induced lockdowns, Frank began providing internet delivery service to his customers. Frank opened the Mudspot on Ninth Street alongside the Mud Coffee Guys.
Later, Prisinzano opened and ran Way, a French Vietnamese restaurant. In addition to these businesses, he founded East Village Radio. Prisinzano was the first DJ there, along with Jorge DoCouto.