The interaction began with Stern quoting Maher when he said that he probably would not get married and he definitely did not want any kids. Stern then routed that emotion into a question, asking him if having a wife would hinder his career as a comedian.
Maher acknowledged that having a wife might affect his stance and performance as a comic but also admitted that was not why he did not have to get married.
Maher confessed that he had quite a few relationships in the past and that a few of them were really amazing.
That being said, he did not find the thought of committing himself to a single person for a long time appealing at all. However, he was still respectful of other people's decision to go that route.
In the simplest terms, he just did not want that path for himself.
