She worked in a Milwaukee beauty supply company before starting her career as an exotic Dancer. After doing photo shoots for men's magazines, she began her career in adult films after meeting Jenna Jameson in 1995, during a photo shoot for Hustler magazine in Jamaica.

In December 2003, Brittany Andrews was appointed to the Women in Adult (WIA) board of Directors as the Talent Liaison. Andrews has promoted using a condom for hardcore sex scenes. She claims that she is very politically active in the adult Business and that her least enjoyable aspect of the Business is standing by and watching the exploitation of women being coerced into performing without condoms.

In February 2008, Andrews retired from porn, and held a Presidents Day party announcing that she was moving to New York to attend film school at the New York Film Academy. However, in 2010 Andrews returned to the Business to star in the adult film Sex and the City: A XXX Parody.

Andrews has started her own mainstream film production company Discipline Filmworks. In 2010, she produced and appeared in the short film Crumble. The film had its world premiere at the 2010 New York International Independent Film and Video Festival, where it won a number of awards including Audience Award for Short Film, Best Actor in a Short Film (for Steven Bauer) and Best Actress in a Short Film (Oksana Lada). She has also acted as executive Producer for the film Trick of the Witch.