She was born on October 23, 1994, to model, musician, and rancher Paul Qualley and actress and model Andie MacDowell. Her given name is Sarah Margaret Qualley. Margaret has two siblings, Justin Qualley and Rainey Qualley, both of whom are American performers and singers. Her hometown in the United States is Kalispell, Montana.
Her parents divorced when she was five years old, in 1999. Margaret is of Caucasian ethnicity and holds an American passport. She enrolled at the North Carolina School of Arts in Winston-Salem, North Carolina. Margaret also studied dance at the American Dance Theatre and the Professional Children’s School in New York. She attended New York University in 2014.