The phrase "deez nuts" was first introduced to the broader public on Dr. Dre's 1992 album "The Chronic," which features a song called "Deeez Nuuuts." Three decades after its introduction, people are still coming up with creative ways to trick people into asking them about it. Thankfully, Dr. Dre's legacy extends far past that phrase, although introducing a new phrase to the cultural lexicon is nothing to sneeze at.
The E10 meme is not revolutionary, then, but is an update on a format that has proven effective for online trolls for decades. Thankfully, the meme is usually intended to be harmless and is far from the worst thing that people can do to one another online, even if some find the meme a little annoying or played out.